QSO environments at intermediate redshifts

We have made a survey of quasar environments at 0.5 < z < 0.8, using a sample of both radio-loud and radio-quiet quasars matched in B-band luminosity. Our observations include images of background control fields to provide a good determination of the field galaxy counts. About 10 per cent of the quasars appear to live in rich clusters, whereas approximately 45 per cent live in environments similar to that of field galaxies. The richness of galaxies within a 0.5 Mpc radius around the radio-quiet quasars is found to be indistinguishable from the richness around the radio-loud quasars, corresponding on average to groups or poorer clusters of galaxies. Comparing the galaxy richness in the radio-loud quasar fields with quasar fields in the literature, we find no evidence of an evolution in the environment with epoch. Instead, a weak, but significant correlation between quasar radio luminosity and environmental richness is present. It is thus possible that the environments of quasars, at least the powerful ones, do not evolve much between the present epoch and z \approx 0.8.Comment: 6 pages, 4 figures, to appear in the proc. of the workshop `QSO hosts and their environments', IAA, Granada 10-12 Jan, 200

Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts

The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20 copies of the cloned globin gene. Rabbit globin transcripts were detected in two of these transformants at steady-state concentrations of 5 and 2 copies per cell. The globin transcripts from one cell line are polyadenylylated and migrate as 9S RNA on methylmercury gels. These transcripts reflect correct processing of the two intervening sequences but lack 48 ± 5 nucleotides present at the 5' terminus of rabbit erythrocyte globin mRNA

Quasar Black Hole Masses from Velocity Dispersions

Much progress has been made in measuring black hole (BH) masses in (non-active) galactic nuclei using the tight correlation between stellar velocity dispersions (sigma) in galaxies and the mass of their central BH. The use of this correlation in quasars, however, is hampered by the difficulty in measuring sigma in host galaxies that tend to be overpowered by their bright nuclei. We discuss results from a project that focuses on z~0.3 quasars suffering from heavy extinction at shorter wavelengths. This makes it possible to obtain clean spectra of the hosts in the spectral regions of interest, while broad lines (like H-alpha) are still visible at longer wavelengths. We compare BH masses obtained from velocity dispersions to those obtained from the broad line region and thus probe the evolution of this relation and BH growth with redshift and luminosity. Our preliminary results show an offset between the position of our objects and the local relation, in the sense that red quasars have, on average, lower velocity dispersions than local galaxies. We discuss possible biases and systematic errors that may affect our results.Comment: 4 pages, to appear in the proceedings of the 2nd Kolkata conference on Observational Evidence for Black Holes in the Universe, ed. S. Chakrabarti (AIP

Quasar 3C 298: a test-case for meteoritic nanodiamond 3.5 µm emission

Aims. We calculate the dust emission expected at 3.43 and 3.53 µm if meteoritic (i.e. hydrogenated) nanodiamonds are responsible for most of the far-UV break observed in quasars. Methods. We integrate the UV flux that hydrogenated nanodiamonds must absorb to reproduce the far-UV break. Based on laboratory spectra of H-terminated diamond surfaces, we analyse the radiative energy budget and derive theoretically the IR emission profiles expected for possible C-H surface stretch modes of the diamonds. Results. Using as test case a spectrum of 3C 298 provided by the Spitzer Observatory, we do not find evidence of these emission bands. Conclusions. While diamonds without surface adsorbates remain a viable candidate for explaining the far-UV break observed in quasars, hydrogenated nanodiamonds appear to be ruled out, as they would give rise to IR emission bands, which have not been observed so far

Increasing the Efficacy of Oncolytic Adenovirus Vectors

Oncolytic adenovirus (Ad) vectors present a new modality to treat cancer. These vectors attack tumors via replicating in and killing cancer cells. Upon completion of the vector replication cycle, the infected tumor cell lyses and releases progeny virions that are capable of infecting neighboring tumor cells. Repeated cycles of vector replication and cell lysis can destroy the tumor. Numerous Ad vectors have been generated and tested, some of them reaching human clinical trials. In 2005, the first oncolytic Ad was approved for the treatment of head-and-neck cancer by the Chinese FDA. Oncolytic Ads have been proven to be safe, with no serious adverse effects reported even when high doses of the vector were injected intravenously. The vectors demonstrated modest anti-tumor effect when applied as a single agent; their efficacy improved when they were combined with another modality. The efficacy of oncolytic Ads can be improved using various approaches, including vector design, delivery techniques, and ancillary treatment, which will be discussed in this review